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Clonazepam 2 mg odt. And lorazepam three times a day. At 10 weeks, the mean score on psychomotor performance test remained unaltered (9.1 vs. 8.4; p>0.05). At 2-month follow-up the mean score on psychomotor performance test declined to 8.1 for haloperidol, 8.2 lorazepam and 8.9 for clonazepam. A positive effect of ketoprofen was observed on the visual analog scale (VAS) ratings of sleepiness (mean 7.6 vs 10.2; p = 0.007). Although there was a tendency for the change from baseline to 6 weeks (change from baseline: −6.6) to be smaller than for the change from 6 weeks to 2 months (change from baseline: −11.6; p = 0.08), this latter change was not significant (p = 0.5). The effects of clonazepam and haloperidol on the VAS ratings of sleepiness are shown in Table 9. Table 9: Effects of clonazepam on VAS ratings sleepiness (A) at baseline, 6 weeks and 2 months. Clonazepam increased the duration of time in bed by 21 min (p<0.001). It improved the mood by 3 out of 4 mood scales, while it worsened the mood scales for irritation, stress and nervousness only by 1 out of 4 (p<0.005). In the psychomotor performance test, mean increase from placebo was 9.8 min, while clonazepam increased the mean time in bed by only 6 min (p<0.001). Although there was no significant difference between placebo and clonazepam in the VAS ratings of sleepiness at baseline, there was a significant difference in the effects of this medication at 6 weeks compared to placebo (p<0.05). The psychomotor performance test showed no difference between groups in the mean change from placebo (between: 2.9 ± 0.3 and 3.4 0.6 min) in the mean change from 6 weeks to 2 months. DISCUSSION The present results demonstrate that antidepressant-like and anxiolytic effects of ketoprofen are sustained over a longer period (2 months) compared to lorazepam and haloperidol. Although no changes were observed in the mean levels of plasma concentration ketoprofen between groups or individuals in the first 2 months, patients treated with haloperidol higher concentrations (50 mg/l) of the ketoprofen metabolite benzhydrotriazole (KHPB) did develop higher baseline plasma concentrations of ketoprofen (P < 0.05) over the 2 months. No significant differences were observed between these 2 groups in any of the 3 psychomotor test assessments. Clonazepam was more efficacious than a placebo and more efficacious than haloperidol. The pharmacodynamics of clonazepam were characterized by fewer side effects and reduced levels of diazepam. The reduction in diazepam suggests that the antimanic effects of clonazepam may result from the anxiolytic action of drug. antidepressant-like and anxiolytic effects of clonazepam were sustained even after 2 months, suggesting a potential antidepressant and anxiolytic efficacy in PD. Patients with PD display impaired self-monitoring of sleep, a symptom many other psychiatric disorders (1). In addition, patients with PD have a.
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